This paper describes the production and characterization of biodegradable microparticles containing glucosinolate hydrolysis products, designed for enteric delivery. Hydroxy propyl methyl cellulose phthalate (HPMCP) microparticles were produced by a double emulsion process using as external phase 0.1% polyvinyl alcohol solution at pH 3.5. Microparticle morphology was characterized by optical and electron microscopy. The release kinetics of the drugs from microspheres was determined using a dialysis method. The double emulsion method here described allows the production of microparticles with high encapsulation efficiency and appropriate dimensional and morphological characteristics for oral administration. Release profile data indicate that the encapsulated drug is released from microparticles with a rate adequate to a sustained enteric delivery
Hydroxy propyl methyl cellulose phthalate (HPMCP) microparticles for enteric delivery of glucosinolate derived products from Cruciferous vegetable
CORTESI, Rita;ESPOSITO, Elisabetta;NASTRUZZI, Claudio
2000
Abstract
This paper describes the production and characterization of biodegradable microparticles containing glucosinolate hydrolysis products, designed for enteric delivery. Hydroxy propyl methyl cellulose phthalate (HPMCP) microparticles were produced by a double emulsion process using as external phase 0.1% polyvinyl alcohol solution at pH 3.5. Microparticle morphology was characterized by optical and electron microscopy. The release kinetics of the drugs from microspheres was determined using a dialysis method. The double emulsion method here described allows the production of microparticles with high encapsulation efficiency and appropriate dimensional and morphological characteristics for oral administration. Release profile data indicate that the encapsulated drug is released from microparticles with a rate adequate to a sustained enteric deliveryI documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
