Continuing our studies on the structure-​activity relationships (SAR) of 4-​iodo-​1-​β-​D-​ribofuranosyl-​3-​carbomethoxy pyrazole (IPCAR)​, the ribofuranosyl moiety has been substituted with acyclic chains, namely 1-​[(2-​hydroxyethoxy)​methyl]​- and 1-​[(1,​3-​dihydroxy-​2-​propoxy)​methyl]​-​pyrazole derivs., with the 2'-​deoxy-​β-​D-​ribofuranosyl group and finally with the 2', 3'-​dideoxy-​D-​glycero-​pentofuranosyl-​moiety. None of the new compds. display any interesting antiviral, antitumor, cytotoxicity, and antibacterial activities up to 300 μM.

Pyrazole related nucleosides 5. synthesis and biological activity of 2'-deoxy-2', 3'-dideoxy- and acyclo-analogs of 4-iodo-1-β-D-ribofuranosyl-3-carboxymethyl pyrazole (IPCAR).

MANFREDINI, Stefano;BARALDI, Pier Giovanni;DURINI, Elisa;VERTUANI, Silvia;
2000

Abstract

Continuing our studies on the structure-​activity relationships (SAR) of 4-​iodo-​1-​β-​D-​ribofuranosyl-​3-​carbomethoxy pyrazole (IPCAR)​, the ribofuranosyl moiety has been substituted with acyclic chains, namely 1-​[(2-​hydroxyethoxy)​methyl]​- and 1-​[(1,​3-​dihydroxy-​2-​propoxy)​methyl]​-​pyrazole derivs., with the 2'-​deoxy-​β-​D-​ribofuranosyl group and finally with the 2', 3'-​dideoxy-​D-​glycero-​pentofuranosyl-​moiety. None of the new compds. display any interesting antiviral, antitumor, cytotoxicity, and antibacterial activities up to 300 μM.
2000
Manfredini, Stefano; Baraldi, Pier Giovanni; Baraldi, P. G.; Bazzanini, Rita; Durini, Elisa; Vertuani, Silvia; Pani, Alessandra; Marceddu, Tiziana; Demontis, Francesca; Vargiu, Laura; LA COLLA, Paolo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1197534
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