The incidence and degree of cysteamine‐ or dulcerozine‐induced duodenal ulcers are increased by systemic capsaicin desensitization (50 mg kg−1 s.c. 4 days before) in adult rats. Acute administration of capsaicin, but not neurokinins or CGRP, produced a small but distinct plasma extravasation (Evans blue leakage) in the rat proximal duodenum which was absent in capsaicin‐pretreated rats. These findings indicate the existence of a capsaicin‐sensitive ‘duodenal defence mechanism’ in rats. 1987 Royal Pharmaceutical Society of Great Britain
Capsaicin‐sensitive mechanisms and experimentally induced duodenal ulcers in rats
ABELLI, Luigi;
1987
Abstract
The incidence and degree of cysteamine‐ or dulcerozine‐induced duodenal ulcers are increased by systemic capsaicin desensitization (50 mg kg−1 s.c. 4 days before) in adult rats. Acute administration of capsaicin, but not neurokinins or CGRP, produced a small but distinct plasma extravasation (Evans blue leakage) in the rat proximal duodenum which was absent in capsaicin‐pretreated rats. These findings indicate the existence of a capsaicin‐sensitive ‘duodenal defence mechanism’ in rats. 1987 Royal Pharmaceutical Society of Great BritainFile in questo prodotto:
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