A catheter inserted into the urethral meatus of urethane-anaesthetised rats was rotated (30 rotations/min) during a 3-min period. One hour later microvascular permeability in the distal urethra was quantified by Evans Blue leakage, which increased significantly over control values. This effect was prevented by about 50% by systemic pretreatment with capsaicin performed in either adult or newborn rats, as well as by bilteral removal of pelvic ganglia. Pretreatment with capsaicin of adult rats, combined to pelvic ganglionectomy, virtually abolished the inflammatory response due to mechanical irritation of the urethra. These results indicate that: I) the increase of vascular permeability provoked by mechanical irritation is nerve-mediated, II) capsaicin-sensitive afferents participate in the inflammatory processes, and III) capsaicin-insensitive nerves, which pass through the pelvic ganglia, contribute to the overall response.
Mechanical irritation induces neurogenic inflammation in the rat urethra.
ABELLI, Luigi;
1991
Abstract
A catheter inserted into the urethral meatus of urethane-anaesthetised rats was rotated (30 rotations/min) during a 3-min period. One hour later microvascular permeability in the distal urethra was quantified by Evans Blue leakage, which increased significantly over control values. This effect was prevented by about 50% by systemic pretreatment with capsaicin performed in either adult or newborn rats, as well as by bilteral removal of pelvic ganglia. Pretreatment with capsaicin of adult rats, combined to pelvic ganglionectomy, virtually abolished the inflammatory response due to mechanical irritation of the urethra. These results indicate that: I) the increase of vascular permeability provoked by mechanical irritation is nerve-mediated, II) capsaicin-sensitive afferents participate in the inflammatory processes, and III) capsaicin-insensitive nerves, which pass through the pelvic ganglia, contribute to the overall response.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
